Lovastatin is an important fungal secondary metabolite inhibiting the enzyme which catalyzes a rate-limiting step in the biosynthesis of cholesterol. As microfungi of the genus Penicillium are active producers of cholesterol lowering agents (statins), studies of this genus have gained considerable momentum. In Malaysia, both agricultural soils and those of natural ecosystems are valuable sources of filamentous fungi, whose biotechnological potential in terms of lovastatin production has not been well investigated. The aim of the present study is to determine lovastatin-producing potential of Penicillium spp. microfungi isolated from soil in Pahang State (Malaysia). Fungal cultures were isolated, purified, and classified based on characters of colony morphology and microscopic features. All identified representatives of Penicillium were tested for their ability to produce lovastatin. Isolates were cultivated in submerged fermentation. High-performance liquid chromatography (HPLC) was used for detection of lovastatin. Among 54 fungal cultures examined, four Penicillium strains were confirmed to produce this statin. The isolate Penicillium sp. ESF2M was the strongest lovastatin producer, with a yield of 20 mg/l. This strain should now be subjected to a further strain improvement program to maximize the yield of this important statin.
Written by November 7, 2019 /Sports News – Local North Sevier’s Kamree Brunson Signs With Otero JC On A Softball Scholarship FacebookTwitterLinkedInEmailSALINA, Utah-Per news released Thursday on the North Sevier High School twitter account, Wolves multi-sport star athlete, senior, Kamree Brunson has signed with the Otero Junior College Rattlers of La Junta, Colo. on a softball scholarship.Brunson is primarily known for her softball skills.Per information from MaxPreps, Brunson, a native of Aurora, Utah, has 11 career home runs, 96 hits and 69 career RBI.Furthermore, she has collected 30 career doubles and 11 career triples for the Wolves. Tags: Kamree Brunson/North Sevier Softball/Otero JC Rattlers Brad James
View post tag: James View post tag: Educate As people across the U.S. recognize the month of May as Asian American/Pacific Islander (AAPI) Heritage Month, Sailors aboard guided-missile destroyer USS James E. Williams (DDG 95), celebrated and educated the crew on AAPI culture and history while underway May 20.The Diversity and Heritage Committee aboard James E. Williams, comprised of Sailors from multiple backgrounds and cultures, serves as an organization driven to celebrate and embrace the different cultures of the crew, including those cultures recognized during AAPI Heritage Month.“Our goal is to educate the crew,” said Yeoman 2nd Class Brandy Stiles, the ship’s secretary and president of the Diversity and Heritage Committee. “We also try to have fun and boost morale with everything that we do.”The committee spreads awareness through flyers, events and celebrations.“We are posting information about AAPI Heritage Month around the ship for everyone to read,” said Electronics Technician 3rd Class Charlotte Williams, secretary of the Diversity and Heritage Committee. “This includes a background and history of the month, as well as famous Americans that are of Asian and Pacific Islander decent.”Apart from educating the crew, the Diversity and Heritage Committee is hosting a special meal prepared by the ship’s culinary specialists, aimed at celebrating Asian and Pacific Island cuisine through a diverse selection and sampling different recipes from around the world.“We prepared a menu to celebrate different cultures and to highlight the versatility of our culinary specialists,” said Culinary Specialist 1st Class Randall Rufolo, the ship’s supply department leading petty officer. “We are preparing a Mongolian barbecue where everything is freshly cooked on the grill to keep with the Asian and Pacific Island tradition, while applying unique twists to standard menu items.”“Every month we try to honor different cultures,” said Williams. “We all come from different walks of life, and the most important aspect of these celebrations is enlightenment.”James E. Williams is deployed to the U.S. 5th Fleet area of responsibility conducting maritime security operations, theater security cooperation efforts and supporting missions as part of Operation Enduring Freedom.[mappress]Naval Today Staff , May 24, 2012 View post tag: Aboard View post tag: Culture View post tag: crew May 24, 2012 View post tag: history Sailors Aboard USS James E. Williams Educate Crew on AAPI Culture and History View post tag: sailors Training & Education Back to overview,Home naval-today Sailors Aboard USS James E. Williams Educate Crew on AAPI Culture and History Share this article View post tag: Navy View post tag: News by topic View post tag: Williams View post tag: USS View post tag: AAPI View post tag: Naval
Two first-year Lincoln students are facing serious disciplinary measures following a drunken incident on Saturday night in which a bench was dropped from a roof at Somerville College. The pair gained entry to Somerville late in the evening during the college’s bop. They found a bench which they proceeded to carry up a flight of stairs to the roof. Whilst carrying it they dropped it and the bench fell, smashing on the car park of the Oratory Catholic Church below.Lincoln College Dean Peter McCulloch confirmed that “an incident of that description is being investigated and handled internally.” An anonymous Lincoln source said that the students had dropped the bench accidentally and had not deliberately thrown it off the roof. The students then came forward the next day to admit to their actions and apologised to representatives of Somerville College.The students are facing a disciplinary committee at their college, which will decide on suitable punishment. McCulloch said that Lincoln are “taking the allegations very seriously.” The disciplinary committee is still hearing the case and is yet to decide on punishment.A number of Lincoln students speculated that the two involved would be likely to have to pay for the cost of the bench and punitive charges. McCulloch said that “monetary fines are part of a large range of disciplinary options within the college rules.”Mark Schaan, Assistant Dean at Somerville said he believed that the bench was worth around £500, although he did not think that it was one of a number of memorial benches owned by Somerville, which hold particular sentimental significance. He did not wish to comment on the ongoing investigations into the incident.None of Cherwell’s sources believe that anyone was hurt in the incident or that any damage was done other than to the bench itself. Members of the clergy at the Oratory Church did not wish to comment on the incident.ARCHIVE: 1st week MT 2005
CHRISTOPHER MUNOZ To the Editor:I am writing to express my gratitude to the City of Bayonne for re-electing me to serve as a Bayonne Board of Education Trustee. I am grateful for your support, and I am honored to serve this wonderful community. Most important, thank you for your participation — and patience — as all of this year’s candidates made our cases to earn your votes. We appreciate voters taking the time to listen, share their opinions and suggestions, and make informed choices. Agree or disagree, this back-and-forth keeps us moving forward as a community. I deeply appreciate your vote of confidence and support. We had a full discussion of the key challenges, crises and issues facing the our school district and community— and I’m grateful to the people for responding so positively and strongly to the case our campaign built on the foundation of my commitment, experience and record.It’s a great honor to continue representing the Bayonne community, and a great responsibility. I’m excited about continuing the work we’ve started together. I truly believe that we have a great deal to be optimistic about — and with continued positive thinking and working together, we can and we will secure the opportunities which are on the horizon and that we deserve.
Last night, Guns N’ Roses brought their current world tour to Sydney, Australia. During the show, frontman Axl Rose surprised the audience by welcoming a special guest. “We’re gonna bring out a friend of ours,” said Rose, “Ladies and gentlemen, [AC/DC guitarist] Angus Young!” Young emerged to help the band run through a pair of AC/DC covers including “Whole Lotta Rosie” and “Riff Raff.” You can watch fan-shot footage of the performance below, courtesy of YouTube user Guilherme Nunes Cunha Neto:Of course, this is not the first time that the worlds of AC/DC and Guns N’ Roses have crossed. Last year, when AC/DC vocalist Brian Johnson had to back out of scheduled tour dates with the band due to hearing loss issues, the band asked Rose to fill in. The band went on to play a number of dates with Axl handling lead vocals.Guns N’ Roses will return to ANZ Stadium today for their second of two performances in Sydney. For a full list of upcoming dates, visit the band’s website.[h/t – Blabbermouth]
Brooklyn Comes Alive announced its massive artist lineup last week, with over 100 artists slated to perform 35+ sets across two days in the heart of Williamsburg. This year, the event is expanding to two days, September 23 & 24, and will take over three of Brooklyn’s premier venues—Brooklyn Bowl, The Hall at MP, and Music Hall of Williamsburg—all within a 10-minute walking radius. While figuring out which musicians will team up for one of the festival’s signature one-off sets has become one of the most fun parts of the Brooklyn Comes Alive experience, we’re ready to roll out some of the surprises. Brooklyn Comes Alive is proud to announce the first of many sets at this year’s event, a star-studded tribute set entitled “The Road Goes On Forever: Celebrating The Music Of The Allman Brothers Band.”The Road Goes On Forever will bring together members of some of the biggest bands in improvisational music to pay homage to the earth-shattering impact of the music of the Allman Brothers Band. Joel Cummins and Kris Myers of Umphrey’s McGee will team up with Al Schnier and Vinnie Amico from moe., Nate Werth from Snarky Puppy, and a pair of musicians from Gregg Allman Band–bassist Brett Bass, and guitarist, vocalist, and musical director Scott Sharrard–to perform some beloved tunes from the Allman Brothers Band catalog.Special guests are also slated to appear throughout the set, including New York guitar prodigy and School of Rock The Musical star Brandon “Taz” Niederauer–who was mentored by both late greats Gregg Allman and Butch Trucks from an early age.When asked what the Allman Brothers mean to him, moe.’s Al Schnier stated:The Allman Brothers “At Fillmore East” changed the landscape of live rock music, & particularly the place of the guitar in an improvisational ensemble forever more. They somehow blended these very American elements of Jazz, Blues, & Soul into something uniquely theirs, yet timeless all the same. And that album, their sound became part of my DNA at an early age. To this day, the twin guitar combo in moe. would not be what it is if not for the path forged by Duane Allman & Dickey Betts.Joel Cummins, keyboardist extraordinaire for Umphrey’s McGee, was equally effusive about the Allman Brothers, explaining:The Allman Brothers are one of rock n roll’s most seminal bands in history, forging a path for many musicians today that have followed in their footsteps. As a keyboardist myself, Gregg Allman & Chuck Leavell‘s masterful work on organ & piano influenced the way I approach music. It will be an honor to pay tribute to a group of musicians Umphrey’s McGee loves and respects so much. Finally, Scott Sharrard had some touching words to share about his mentor and former bandmate, Gregg Allman. Sharrard was the musical director for the final eight years of the Gregg Allman Band, and also was a frequent collaborator of Allman’s in his later years, helping him to write new music and to shape his live show. Scott will serve as musical director for The Road Goes On Forever, and he had this to say about this set at Brooklyn Comes Alive:What Gregg Allman and Butch Trucks did was rain truth daggers of love and unity in every salvo of sound from the stage. One true note can slice into every heart. I believe this was their goal every time that they took the stage, I never saw them miss. It will be a pleasure to honor these founding members of one of the greatest rock bands of all time. Alongside some friends, both old and new, we will do our best to “hit the note” at Brooklyn Comes Alive. The 2017 Brooklyn Comes Alive lineup features members of Umphrey’s McGee, moe., The Disco Biscuits, The String Cheese Incident, Trey Anastasio Band, and so many more. Iconic legends such as John Scofield, George Porter Jr., Cyril Neville, DJ Premier, Johnny Vidacovich, and Henry Butler will join members of nationally-touring bands such as GRAMMY-winners Snarky Puppy, The Meters, Primus, Soulive, Lettuce, The Motet, Lotus, Railroad Earth, The Infamous Stringdusters,Yonder Mountain String Band, The Russ Liquid Test, SunSquabi, Pendulum, Destroid, The Crystal Method, Midnight North, Aqueous, Kung Fu, Electric Beethoven, and more. Check out the full lineup of artists below, and stay tuned for upcoming announcements about bands, supergroup formations, and special tribute sets.Tickets Are On Sale Now!Each ticket grants attendees in-and-out access to all three venues, creating the feeling of an indoor music festival all within the heart of Williamsburg. In true Brooklyn Comes Alive-fashion, a brunch set will kick off the music each day, and performances will continue into the early hours of the morning with special late-night performances.To find out more about ticketing, VIP options, and lodging, head to the festival website.
This past Saturday, January 27th, following the completion of their annual Island Exodus destination event in Jamaica, Gov’t Mule headed to Boca Raton, FL for a performance at Florida Jazz and Blues Jam, where they shared the bill with The Devon Allman Project, Walter Trout, Robben Ford, Kenny Neal, and Marcia Ball, as well as a slew of special guests.The highlight of the Mule set came during its final number, when the Mule welcomed several guests, including Peter Levin (formerly of Gregg Allman Band) as well as two sons of members of the Allman Brothers Band (Devon Allman and Duane Betts) to help them through a roaring rendition of former ABB live staple “Statesboro Blues”. The classic blues tune came to its climax when Warren Haynes, while still singing the melody of the song, invited told the audience that they were going to close it out with everybody playing at the same time–and bobbing, and weaving, and dancing around–“just like we would down in New Orleans.” The extra-large group did just that, as all three guitarists, both keyboardists, and the rest of Mule wailed away for a few gloriously chaotic bars.Watch Gov’t Mule’s “Statesboro Blues” with Devon Allman and Duane Betts at Florida Jazz and Blues Jam at Sunset Cove in Boca Raton, FL via YouTube user yosull1):Below, listen to full audio of Gov’t Mule’s performance at Sunset Cove Amphitheater featuring appearances from Devon Allman and Duane Betts, via taper Jamgrasss, uploaded by Jam Buzz:SETLIST: Gov’t Mule | Florida Jazz and Blues Jam | Sunset Cove Amphitheatre | Boca Raton, FL | 1/27/18SET: Railroad Boy > Thorazine Shuffle, Band of the Deep > Rocking Horse > Game Face > Revolution Come, Revolution Go > The Sky Is Crying*, Soulshine > Tupelo Honey > Soulshine, I’m A RamEncore: Statesboro Blues***Peter Levin on Keys, Walter Trout on Guitar/vocals**Duane Betts on Guitar, Pete Levin on Keys, Devon Allman on Guitar/backup vocalsNext up for Gov’t Mule is a run through Australia in March. For a full list of dates, head to the band’s website.[Cover photo via YouTube user yosull1]
It might seem strange that the man who touts the high-tech advances of the digital age also loves a good rotary phone and medieval manuscript.But for Jeffrey Schnapp, whose work and passion exist largely at the intersection of disparate worlds, the three complement each other perfectly.A yellow, doughnut-shaped telephone from the 1950s sits in his airy Harvard office, a nod to kitsch and culture. Nearby are old typewriters from the early part of the 20th century and cumbersome calculating machines that he uses to maintain the tactile feel of an earlier era under his fingertips. Older still are the folios that litter the floor, unbound sections from a catalog of the Roman Cassinate library of 1725.A pioneer in digital humanities, Schnapp considers the Internet a tool that can illuminate ephemera, that can unlock scholarly possibilities and connections between the physical and the virtual, the modern and the ancient, and that can help to forge dynamic new forms of scholarship in the humanities.“With the emergence of the Web as the defining public space of our era, the preconditions have become available to think boldly about reshaping the arts and humanities fields in ways that permit the building of bigger pictures,” said Schnapp. “The Internet has the potential to bring scholarship out of the silos in which it tends to live into interdisciplinary, even societywide conversations.”The professor of Romance languages and literatures works to harness that digital drive, and is developing a multichanneled approach to scholarship with metaLAB at Harvard, a new laboratory hosted at Harvard’s Berkman Center for Internet & Society that weds technical innovation with scholarly experimentation. It also promotes the reinvigoration of traditional forms of scholarship through the use of new media and computational tools. Schnapp, who founded the lab last year, spearheaded a similar effort at Stanford University starting in 1999.An example of a “bigger picture” taking shape at the new lab is the Digital Archive of Japan’s 2011 Disasters. In collaboration with Harvard’s Reischauer Institute of Japanese Studies, the lab is building a user interface that will link separate digital archives into a type of “active public space.” With public input, the archive aims to capture everything from images and print stories to text messages, websites, Twitter streams, and personal stories from the tragedies.“It’s an extraordinary opportunity to enhance our ability to work with large archival corpora and to think about models of preservation and access that very specifically exploit the powers of the digital realm,” he said.Schnapp’s interest in merging different fields is no accident. He is a Renaissance man. He speaks six languages fluently. He is a medieval Italian scholar, a designer, curator, and occasional computer programmer. He is also a former semi-professional motorcycle racer, a pursuit that left him with a host of trophies that occupy a corner of his office, along with “a rich collection of broken bones, the inescapable downside of participation in motor sports.”In addition to his other duties, he is a fellow at the Berkman Center and a member of the teaching faculty at the Harvard Graduate School of Design.He developed his passion for languages while growing up in Mexico City, where his father was working. He graduated from Vassar College with a degree in Hispanic studies and a minor in studio art, and received a Ph.D. in comparative literature from Stanford University in 1983.While investigating a position as director of the humanities center at the University of Washington, he was struck by the rich connections the school was developing between its humanities-based research centers and the city’s public institutions. The experience convinced him of the need to rethink the boundaries of academia.“I realized we needed to reshape the public space as a place where forms of high-quality, cutting-edge scholarship could speak to audiences that will never buy a scholarly monograph, not to mention pick up a specialized journal and read an article.”Ultimately, he brought that philosophy to Stanford and to the Stanford Humanities Lab, and to such innovative projects as the lab’s HyperCities, a prize-winning Web platform that virtually connects visitors to a city’s historical narratives. It was incubated at the Stanford Humanities Lab, and starting in 2004 further developed by Todd Presner and his team at the University of California, Los Angeles.“It’s impossible to tell the legion of stories that make up an urban reality; there’s so many crisscrossing threads,” said Schnapp. “As scholars, we are always forced to choose a slice.”But with HyperCities, visitors and scholars can have it all. Physical maps can be “layered historically” and used to organize materials involving the archaeological and architectural history of a city, the history of its people, its transportation grid, and its economy, all on one setting. The project “goes beyond the print-based model of scholarship, where we can tell those multiple stories and explore the places where they collide and crisscross.”At Harvard, Schnapp sees his mission as that of a catalyst who “can bring a less risk-averse culture to the humanities, and a more experimental ethos that is actively engaged with the task of modeling what knowledge should look like in the 21st century.”“What’s needed,” he said, “is a rethinking of the map of knowledge.”
Spanish government looks to reform energy sector FacebookTwitterLinkedInEmailPrint分享Bloomberg:The Spanish government is exploring ways to persuade investors to finance a 100 billion-euro ($116 billion) transformation of its energy system as it tries to move beyond past policy mistakes that led to widespread losses and lawsuits.The Socialist administration is drawing up plans to expand renewable power generation, modernize its transport system and refit buildings to make them more energy efficient through 2030. But the effort to mobilize private investment is hampered by ongoing legal disputes from the party’s last green energy push a decade ago, which saw over-generous solar power subsidies cut retroactively.“We have to craft carefully a proposal that is adequate, credible and sound in terms of new investments, both for national and foreign investors, and also providing some recognition about what happened,” Teresa Ribera, minister for the ecological transition, said in an interview at her office in Madrid. “It can be through regulatory means or it can be via fiscal means.”Ribera has limited room for maneuver because the government is still fighting legal claims from investors over cuts in subsidies for photovoltaic power plants. Spain became the world’s biggest installer of PV panels in 2008 after the government misjudged the amount of subsidy required to stimulate investment. The payments were gradually reduced over successive years — leaving some plants struggling to cover their financing costs — as they began to jeopardize the public finances.A second problem for the minority administration is its lack of support in parliament, where the governing party has just 84 of 350 lawmakers. Ribera said she is aiming to win cross-party support for her plans but can also use administrative levers to push through some measures if she is blocked by opposition parties.Among her first moves, Ribera aims to remove a levy on Spaniards who installed solar panels on their homes by the end of November. She said both the left-wingers of Podemos and the liberals of Ciudadanos have in the past signaled they would support the decision, but the government can also push through the change by decree if necessary.More: Spain Aims to Win Investors for $116 Billion Energy Refit